The increasing amount of genome sequence data is the basis for understanding life as a molecular system and for developing medical, pharmaceutical, and other practical applications. Since 1995 we have been developing knowledge-based methods for uncovering higher-order systemic behaviors of the cell and the organism from genomic and molecular information. The reference knowledge is stored in KEGG, Kyoto Encyclopedia of Genes and Genomes, and associated bioinformatics technologies are being developed both for basic research and practical applications.

Example for searching KEGG with Perl:

See this for more information.

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#!/usr/bin/perl
use SOAP::Lite;
$wsdl   = 'http://soap.genome.jp/KEGG.wsdl';
$serv   = SOAP::Lite->service($wsdl);
$offset = 1;
$limit  = 5;
$top5   = $serv->get_best_neighbors_by_gene('vvi:100261203', $offset, $limit);
foreach $hit (@{$top5}) {
 print "$hit->{genes_id1}\t$hit->{genes_id2}\t$hit->{sw_score}\n";
}